![]() ![]() ![]() In a series of 21 individuals, significantly reduced total hippocampal volumes were observed in CO-poisoned patients, and overall neuropsychological impairment was correlated with hippocampal volume obtained from quantitative MRI ( 12). ( 11), conducted on four patients with CO intoxication and 28 patients with other various toxic causes of leukoencephalopathy, none of the imaging markers seemed to correlate with clinical outcomes. ( 10) described that extensive areas of decreased fractional anisotropy in various regions of the WM tract were detectable after four to six months of hyperbaric-oxygen treatment, and correlated with cognitive deficits. ( 9) reported that ADC values of globus pallidus and corpus callosum, correlated with multiple cognitive test scores. Several studies focused on using neuroimaging findings to predict clinical outcomes in patients with CO intoxication, have been performed however, they have not shown consistent results. These neuroimaging findings were related to necrosis in the globus pallidus and demyelination in the cerebral WM, as documented in a report of autopsy findings by Lapresle and Fardeau ( 7, 8). Additionally, high signal intensity (SI) on DWI and low value on apparent diffusion coefficient (ADC) map in the globus pallidus in the acute phase, and in the cerebral WM in the acute through chronic phases following CO intoxication, have been demonstrated ( 5, 6). Most imaging findings of damaged brains from CO poisoning, are bilateral hyperintensities in the globus pallidus, periventricular white matter (WM), and centrum semiovale (CS) on T2-weighted images ( 4). However, there are no clinical or laboratory results available to correlate occurrence of these complications ( 3).Ĭonventional MRI findings of CO poisoning, are well described. Apart from acute symptoms of cerebral impairment after exposure to CO, delayed onset of neuropsychiatric symptoms has been reported in 10–30% of survivors, after three to 240 days of exposure. Clinical symptoms of acute CO poisoning are non-specific, and patients can present a variety of symptoms such as headache or dizziness resulting from mild exposure, confusion, loss of consciousness, or even death, after severe exposure ( 2). ![]() Carbon monoxide (CO) poisoning is common, and, in the United States, ~50,000 patients annually visit the emergency department because of CO poisoning ( 1). ![]()
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